Workplan

Study: Case-Control

  • Cases: Drinkers with Alcoholic Liver Cirrhosis (ALC)
  • Controls: Drinkers without ALC
  • N = 5000 of homogenous ethnicity
  • Multinational consortium consisting of hepatologists, molecular biologists, geneticists, bioinformaticians

Methodology

  • Ethics approval for recruitment
  • Well defined inclusion/exclusion criteria
  • Data collection using semi-structured questionnaire based interviews for clinical characteristics, alcohol history and use, biochemistry, medication, demographics,  background, anthropomorphic measures
  • Blood (DNA, RNA) and serum collection
  • Genome Wide Association studies: Single Nucleotide Polymorphisms (SNPs) chips/ Sequencing
  • Data analysis, HAPMAP
  • Identification of genetic variants affecting risk for this disease.
  • Insights into the ALC pathogenic  process
  • Identification of genetic biomarkers and their clinical correlates.